> FOAM FATAL ERROR: Maximum number of iterations exceededįrom function Foam::scalar Foam::species::thermo::T(Foam::scalar, Foam::scalar, Foam::scalar, Foam::scalar (Foam::species::thermo::*)(Foam::scalar, Foam::scalar) const, Foam::scalar (Foam::species::thermo::*)(Foam::scalar, Foam::scalar) const, Foam::scalar (Foam::species::thermo::*)(Foam::scalar) const) const in file /home/ubuntu/OpenFOAM/OpenFOAM-4.1/src/thermophysicalModels/specie/lnInclude/thermoI.H at line 66. I have some problem with chtMultiRegionSimpleFoam The parameter C is the estimate of IC50 or EC50. This is a standard function in most statistics software. Is frequently used to fit dose-response curves. To calculate IC50, input 50 in the "INTERPOLATE." table (highlighted in blue), the result will be shown on the right (highlighted in green).įor log-transformation, go to Data Transformation on the upper-right, input 3 in the DOSE (X-axis)/1st cell.įour-parameter (A, B, C, D) logistic function (or Sigmoidal) Input your data in the left columns, and your results will be shown in the right half of the Excel table. The response-curve fits better to a straight line if the x-axis is logarithm-transformed.ĮD50V10 (Readme) is an Excel add-in for calculating IC50/EC50 values. IC50 value is then estimated using the fitted line, i.e.,įrequently, linear regression is not a good fit to dose-response data. The simplest estimate of IC50 is to plot x-y and fit the data with a straight line (linear regression). To calculate IC50, you would need a series of dose-response data (e.g., drug concentrations x1, x2. I have described as per excel sheet 2007 version. Then you can calculate your IC50 value in the same way e.g. You will get a different equation "y = m x + (or) - c, where c will be another numerical value which is your intercept value. You can also try by not checking the box "intercept = 0". There, you type "=(50/m)", where m is the numerical value displayed on the equation of your graph, and hit enter. Click on any cell of your excel sheet where you want to display your IC50 value. Using the equation you got, you can calculate IC50.Ħ. m is the slope which will have a numerical value.ĥ. You will get a linear curve on your graph with an equation "y = m x". Set your trendline to "linear", "automatic", check the box "intercept = 0" and "display equation on chart".Ĥ. From the drop down menu, click on "more trendline options".ģ.
You will find the tap for it at the top of your excel sheet.Ģ. After you have entered your data on inhibition % and concentration in excel sheet (in adjacent columns), then plot your graph with a scatter diagram. But if your question means what I think it is, then the answer is like this: -ġ.
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